Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children
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چکیده
منابع مشابه
Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children
INTRODUCTION Differentiating between sterile inflammation and bacterial infection in critically ill patients with fever and other signs of the systemic inflammatory response syndrome (SIRS) remains a clinical challenge. The objective of our study was to mine an existing genome-wide expression database for the discovery of candidate diagnostic biomarkers to predict the presence of bacterial infe...
متن کاملInterleukin-27: a novel biomarker in predicting bacterial infection among the critically ill
INTRODUCTION A continued need exists for effective diagnostic biomarkers in bacterial sepsis among critically ill patients, despite increasing use of available biomarkers such as procalcitonin (PCT). Interleukin-27 (IL-27) has shown early promise in a recent preliminary study, exhibiting high specificity and positive predictive values for bacterial infection in critically ill children. This val...
متن کاملUrinary interleukin-18 is an acute kidney injury biomarker in critically ill children.
BACKGROUND Urinary interleukin-18 (uIL-18) is an earlier acute kidney injury (AKI) biomarker than serum creatinine (SCr) in specific populations. In the present study, the relationship between uIL-18 and AKI was determined in a heterogeneous group of critically ill children. METHODS We studied critically ill children to determine whether uIL-18 was an early predictor of AKI. SCr was determine...
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BACKGROUND AND OBJECTIVES Acute kidney injury (AKI) complicates the course of disease in critically ill patients. Efforts to change its clinical course have failed because of the fail in the early detection. This study was designed to assess whether heat shock protein (Hsp72) is an early and sensitive biomarker of acute kidney injury (AKI) compared with kidney injury molecule (Kim-1), neutrophi...
متن کاملInterleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement
Enterovirus 71 (EV71) is a major pathogen for severe hand, foot, and mouth disease (HFMD), which leads to severe neurological complications and has high morbidity and mortality. Reliable biomarker for the prediction of deterioration in EV71-infected children with central nervous system (CNS) involvement may reduce the cardiopulmonary failure and mortality. Here, we found that serum IL-27 levels...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2012
ISSN: 1364-8535
DOI: 10.1186/cc11847